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M8046

Sigma-Aldrich

Mifepristone

≥98%

Synonym(s):
11β-(4-Dimethyl­amino)­phenyl-17β-hydroxy-17-(1-propynyl)­estra-4,9-dien-3-one, RU-38486, RU-486
Empirical Formula (Hill Notation):
C29H35NO2
CAS Number:
Molecular Weight:
429.59
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

sterility

non-sterile

Assay

≥98%

form

powder

technique(s)

inhibition assay: suitable

solubility

ethanol: 50 mg/mL, clear, greenish-yellow

originator

Danco Laboratories

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C

InChI

1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChI key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

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This Item
1443759475838M3047
Mifepristone ≥98%

Sigma-Aldrich

M8046

Mifepristone

Mifepristone United States Pharmacopeia (USP) Reference Standard

USP

1443759

Mifepristone

Mifepristone A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

Sigma-Aldrich

475838

Mifepristone

Mizoribine ≥98% (TLC)

Sigma-Aldrich

M3047

Mizoribine

assay

≥98%

assay

-

assay

≥99% (titration)

assay

≥98% (TLC)

form

powder

form

-

form

solid

form

-

technique(s)

inhibition assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

solubility

ethanol: 50 mg/mL, clear, greenish-yellow

solubility

-

solubility

ethanol: 10 mg/mL

solubility

-

originator

Danco Laboratories

originator

-

originator

-

originator

-

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

Application

Mifepristone has been used:
  • to induce damage against the proliferative and secretory phase of endometrial stromal cells
  • to establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs
  • to activate geneswitch gal4 in flies
  • to study the effects of sex steroids on prostaglandin secretion

Biochem/physiol Actions

Therefore, mifepristone is considered to be a potent abortifacient. It is also known to inhibit human chorionic gonadotropin. Mifepristone results in decidual necrosis.
Mifepristone (RU-486) has activity as both a progesterone receptor antagonist and a glucocorticoid receptor antagonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Danco Laboratories. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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