MilliporeSigma
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I7908

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Synonym(s):
T-cell growth factor, Interleukin-2, IL-2
MDL number:
NACRES:
NA.75

Quality Level

biological source

human

recombinant

expressed in Pichia pastoris

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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