MilliporeSigma
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I2644

Sigma-Aldrich

Interleukin-2 human

IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):
T-cell growth factor, Interleukin-2, IL-2, hIL-2
MDL number:
NACRES:
NA.77

Quality Level

biological source

human

recombinant

expressed in E. coli

form

lyophilized powder

potency

≤700 EC50

quality

endotoxin tested

mol wt

15.5 kDa

packaging

pkg of 5X10 μg
pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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General description

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Packaging

10 μg in poly bottle

Biochem/physiol Actions

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized, 0.2 μm filtered, no additives.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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