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I1252

Sigma-Aldrich

DL-Isocitric acid trisodium salt hydrate

≥93%

Synonym(s):

threo-DsLs-Isocitric acid trisodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C6H5Na3O7 · xH2O
CAS Number:
1637-73-6
Molecular Weight:
258.07 (anhydrous basis)
MDL number:
MFCD00149284
UNSPSC Code:
41116107
PubChem Substance ID:
24895923
NACRES:
NA.25

assay

≥93%

SMILES string

O.[Na+].[Na+].[Na+].OC(C(CC([O-])=O)C([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Na.H2O/c7-3(8)1-2(5(10)11)4(9)6(12)13;;;;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);;;;1H2/q;3*+1;/p-3

InChI key

BPEHKAXIRZOKIS-UHFFFAOYSA-K

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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An-Ping Lin et al.
Biochemistry, 50(38), 8241-8250 (2011-08-25)
Yeast NAD(+)-specific isocitrate dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a catalytic IDH2 subunit and a regulatory IDH1 subunit. Despite structural predictions that the enzyme would contain eight isocitrate binding sites, four NAD(+) binding sites
Alexander B Taylor et al.
The Journal of biological chemistry, 283(16), 10872-10880 (2008-02-08)
Mitochondrial NAD(+)-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative pathways in response to cellular energy levels. Here we present the first structures of a eukaryotic member of this enzyme family, the allosteric, hetero-octameric, NAD(+)-specific IDH
Metabolism, gliomas, and IDH1.
Jan Smeitink
The New England journal of medicine, 362(12), 1144-1145 (2010-03-26)
Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry.
Akane Kawamura et al.
Cell cycle (Georgetown, Tex.), 10(17), 2819-2820 (2011-08-23)
Grant C Bullock et al.
Blood, 116(1), 97-108 (2010-04-22)
Human red cell differentiation requires the action of erythropoietin on committed progenitor cells. In iron deficiency, committed erythroid progenitors lose responsiveness to erythropoietin, resulting in hypoplastic anemia. To address the basis for iron regulation of erythropoiesis, we established primary hematopoietic
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