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HPA040902

Sigma-Aldrich

Anti-MYO5B antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):
Anti-Kiaa1119, Anti-Myosin vb
Human Protein Atlas Number:

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

packaging

antibody small pack of 25 μL

enhanced validation

independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: 1:200- 1:500

immunogen sequence

NLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLK

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MYO5B(4645)

General description

Myosin VB (MYO5B) gene spanning 372,296 bases on genomic DNA with 42 exons is mapped to human chromosome 18q21.1. The gene codes for ubiquitously expressed myosin Vb protein. MYO5B contains N-terminal motor domain and C-terminal cargo-binding domain.

Immunogen

myosin VB recombinant protein epitope signature tag (PrEST)

Application

Anti-MYO5B antibody produced in rabbit has been used in immunostaining and western blot analysis.

Biochem/physiol Actions

Myosin VB (MYO5B) acts as a motor for actin dependent organelle trafficking. Mutation or loss of MYO5B gene is associated with the development of an autosomal recessive syndrome, microvillus inclusion disease (MVID). Decreased expression of the protein has been observed in patients of gastric cancer. Therefore, MYO5B might act as a potential biomarker for gastric cancer. MYO5B interacts with Ras-related proteins 8a and 11a (Rab8a–Rab11a) component and stimulates stretch-induced exocytosis in bladder umbrella cells.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST81706.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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