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G7126

Sigma-Aldrich

Glycine

ReagentPlus®, ≥99% (HPLC)

Synonym(s):
Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
Beilstein:
635782
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

product line

ReagentPlus®

Assay

≥99% (HPLC)

form

powder

technique(s)

western blot: suitable

impurities

≤0.01% Ammonia

loss

≤0.2% loss on drying

color

white to off-white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H2O: 200 mg/mL, clear, colorless to faintly yellow

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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Glycine ReagentPlus®, ≥99% (HPLC)

Sigma-Aldrich

G7126

Glycine

Glycine suitable for electrophoresis, ≥99%

Sigma-Aldrich

G8898

Glycine

Glycine granulated, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.03669

Glycine

Glycine ACS reagent, ≥98.5%

Sigma-Aldrich

410225

Glycine

product line

ReagentPlus®

product line

-

product line

EMPROVE® EXPERT

product line

-

assay

≥99% (HPLC)

assay

≥99%

assay

99.0-101.0% (calculated on dried substance, perchloric acid titration)

assay

≥98.5%

form

powder

form

powder

form

granular

form

crystals, powder or granules

technique(s)

western blot: suitable

technique(s)

electrophoresis: suitable, western blot: suitable

technique(s)

inhibition assay: suitable

technique(s)

-

impurities

≤0.01% Ammonia

impurities

≤0.01% Insoluble matter

impurities

-

impurities

H2SO4, passes test (darkened), Hydrolyzable subsances, passes test

color

white to off-white

color

white to off-white

color

-

color

-

General description

Glycine is a non-chiral amino acid. Glycine is a molecule with pI of 6.7, which is similar to the pH of stacking region in polyacrylamide gels. It has advantage of low mobility, hydrophobicity and it does not associate with proteins.

Application

  • Glycine has been added in the transfer buffer during western blotting procedure.
  • It has been used in the solution prepared for dissolving formazan crystals in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) cytotoxicity assay.
  • It has been used for terminating the rat basophilic leukemia (RBL) assay.

Biochem/physiol Actions

Glycine is an inhibitory neurotransmitter in the central nervous system and works as an allosteric regulator of NMDA (N-methyl-D-aspartate) receptors. It is involved in processing of motor and sensory data, thereby regulating movement, vision and audition.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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