D141

Digitonin

Used as non-ionic detergent

• Synonym(s): Digitin
• Empirical Formula (Hill Notation): C₅₆H₉₂O₂₉
• CAS Number: 11024-24-1
• Molecular Weight: 1229.31
• Beilstein: 78654
• EC Number: 234-255-6
• MDL number: MFCD00077729
• PubChem Substance ID: 24893429
• NACRES: NA.25

Properties

• Quality Level: 200
• form: powder
• optical activity: [α]20/D −54°, c = 2.8 in methanol(lit.)
• mol wt: micellar avg mol wt 70,000
• aggregation number: 60
• CMC: <0.5 mM (20-25°C)
• mp: 230-240 °C (dec.) (lit.)
• solubility: H₂O: ~5 % (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.)
• SMILES string: C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H
• InChI: 1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36-,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1
• InChI key: UVYVLBIGDKGWPX-KUAJCENISA-N

Description

Application

Digitonin has been used in a study to assess a procedure for isolating mitochondria from ascites tumor cells. It has also been used in a study to investigate its effect on the cytotoxicity of plant secondary metabolites in cancer cells.

Quality

Preparation is free of water-insoluble constituents.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 - H373
• Precautionary Statements: P301 + P310 + P330 - P314
• Hazard Classifications: Acute Tox. 3 Oral - STOT RE 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves