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Key Documents

C9781

Sigma-Aldrich

Tyr-C-Peptide human

≥95% (HPLC)

Synonym(s):

Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg, Tyr-Insulin C chain

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About This Item

Empirical Formula (Hill Notation):
C162H268N50O54
CAS Number:
139532-11-9
Molecular Weight:
3780.16
MDL number:
MFCD00082116
UNSPSC Code:
12352209
NACRES:
NA.26

product name

Tyr-C-Peptide human, ≥95% (HPLC)

Quality Level

200

assay

≥95% (HPLC)

form

powder

composition

Peptide content, ~65%

color

white

UniProt accession no.

P01308

storage temp.

−20°C

Gene Information

human ... INS(3630)

Amino Acid Sequence

Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg

Biochem/physiol Actions

Tyr-C-Peptide is derived from genetically modified Arg32Tyr human pro-insulin mutants by trypsin and carboxypeptidase B codigestion.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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H Sun et al.
Applied biochemistry and biotechnology, 55(3), 167-174 (1995-12-01)
C-peptide radioimmunoassay (C-peptide RIA) is widely used in determination of pancreatic B-cell secretion activity. 125I labeled Tyr-C-peptide is indispensable in C-peptide RIA kit. Herein we discuss a way of obtaining recombinant Tyr-C-peptide. Arg32Tyr human pro-insulin mutant (R32Y-proinsulin) gene was constructed

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