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C4396

Sigma-Aldrich

Carbonic Anhydrase I from human erythrocytes

Synonym(s):
Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase Isozyme I
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:

form

powder

Quality Level

specific activity

100-500 W-A units/mg protein

mol wt

30 kDa

color

white

pI 

~6.6

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... CA1(759)

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Application

Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). Chaperone-like α-crystallin binds to this state of the enzyme and prevents its aggregation. The enzyme from sigma has been used for the analysis of thermodynamic stability of the enzyme. Furthermore, its clinical significance has been evaluated in human non-small cell lung cancer.

Packaging

1, 5, 25 mg in glass bottle

Biochem/physiol Actions

Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in various pathologies such as glaucoma, epilepsy and Parkinson′s disease.

Unit Definition

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

Preparation Note

chromatographically
purified.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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Technical Information

Newsletter / Publication

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