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A9477

Sigma-Aldrich

Aldosterone

≥95% (HPLC)

Synonym(s):
11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
Molecular Weight:
360.44
Beilstein:
3224996
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

sterility

non-sterile

assay

≥95% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

Gene Information

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Application

Aldosterone has been used:
  • as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG)
[36]
  • in combination with salt to induce renal injury in mice
  • [22]
  • to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice
  • [21]
    The d-isomer of aldosterone is considered to be the biologically active isomer.

    Packaging

    5, 25 mg in glass insert
    100 mg in poly bottle

    Biochem/physiol Actions

    Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K+ and renal reabsorption of Na+.[18] It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules.[19] Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage.[20] It contributes to the progression of chronic kidney disease(CKD).[22] Aldosterone is part of the renin-angiotensin-aldosterone system (RAAS).[21]

    Other Notes

    Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

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    Certificate of Origin

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