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Key Documents

A5597

Sigma-Aldrich

Xylene Substitute

greener alternative

Synonym(s):

for microscopy

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About This Item

EC Number:
UNSPSC Code:
12352200

application(s)

hematology
histology

greener alternative category

General description

Compatible with all tissue processors. May not be compatible with all permanent mounting media.

Application

Xylene Substitute has been used to dewax or de-paraffinize the specimen sections after the staining process.We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing. For more information see www.sigmaaldrich.com/catalog/papers/19608083.

pictograms

FlameHealth hazard

signalword

Danger

Hazard Classifications

Asp. Tox. 1 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

63.0 °F - closed cup

flash_point_c

17.2 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jiaming Guo et al.
Scientific reports, 9(1), 14578-14578 (2019-10-12)
Analysis of three-dimensional biological samples is critical to understanding tissue function and the mechanisms of disease. Many chronic conditions, like neurodegenerative diseases and cancers, correlate with complex tissue changes that are difficult to explore using two-dimensional histology. While three-dimensional techniques
Jiaming Guo et al.
Biomedical optics express, 11(1), 99-108 (2020-02-06)
Immunohistochemical techniques, such as immunofluorescence (IF) staining, enable microscopic imaging of local protein expression within tissue samples. Molecular profiling enabled by IF is critical to understanding pathogenesis and is often involved in complex diagnoses. A recent innovation, known as microscopy
René J Buesa et al.
Annals of diagnostic pathology, 13(4), 246-256 (2009-07-18)
After the hazardous effects of xylene became indisputable in the 1970s, many potential substitutes became available, some with as many if not more hazards. This article discusses the inadequacy of 5 vegetable oils as substitutes, as well as the characteristics
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting

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