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A5486

Sigma-Aldrich

Azoxymethane

13.4 M, ≥98%

Synonym(s):
AOM
Linear Formula:
CH3N=N(→O)CH3
CAS Number:
Molecular Weight:
74.08
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥98%

form

liquid

composition

methylene chloride, ≤1% (solvent)

concentration

13.4 M

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Packaging

25, 100 mg in ampule

Biochem/physiol Actions

Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Other Notes

It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

75.2 °F

Flash Point(C)

24 °C

Certificate of Analysis

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Certificate of Origin

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