62966
L-α-Lysophosphatidylinositol sodium salt from soybean
≥98.0% (TLC)
Synonym(s):
1-Acyl-sn-glycero-3-phospho-(1-D-myo-inositol)
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About This Item
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biological source
soybean
Quality Level
assay
≥98.0% (TLC)
form
powder
impurities
primarily palmitic acid
stearic acid
functional group
phospholipid
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
Biochem/physiol Actions
Lysophosphatidylinositol, an endogenous phospholipid, is a novel ligand for the orphan G protein-coupled receptor 55 (GPR55) . Lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT (nuclear factor of activated T cells) activation in human embryonic kidney 293 cells .
Preparation Note
by phospholipase A2-treatment of 3-sn-phosphatidylinositol
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Christopher M Henstridge et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(1), 183-193 (2008-09-02)
The endogenous phospholipid l-alpha-lysophosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein-coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways activated by LPI in a human embryonic kidney (HEK) 293 cell
Saori Oka et al.
Biochemical and biophysical research communications, 362(4), 928-934 (2007-09-04)
GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably
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