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Nonidet P 40, Octylphenoxy poly(ethyleneoxy)ethanol, branched, Nonylphenyl-polyethylenglycol
Linear Formula:
CAS Number:

Quality Level



mol wt

~603.0 g/mol


thin layer chromatography (TLC): suitable

refractive index

n20/D 1.492


0.08 mM (20-25°C)

transition temp

cloud point 63-67  °C


1.06 g/mL at 20 °C

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤1000 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤1000 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg





InChI key


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General description

IGEPAL® CA-630 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40.


IGEPAL® CA-630 has been used:
  • In phosducin co-precipitation assay for pull down of Epitope-Tagged HAGγ1 and HAGγ1C71S
  • As a component of lysis buffer for cell culture and sample preparation for MAPK (mitogen-activated protein kinases) analysis, Immunoblotting
  • In the extraction of cells in Oil Red O staining procedure to visualise lipid formation in cells during adipogenesis
  • As a component of lysis buffer containing Tris-HCl, NaCl and EDTA for immunoblotting experiment

Other Notes

Nonionic, non-denaturing detergent


Chemically indistinguishable from Nonidet P-40, which is no longer commercially available.


May develop turbidity or sediment during storage. A clear liquid can be obtained on heating to 40°C.
May become turbid on storage; a clear product can be obtained on heating to 40°C.

Legal Information

IGEPAL is a registered trademark of Solvay
Nonidet is a trademark of Shell Chemical Co.

Signal Word


Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids



Flash Point(F)

483.8 °F

Flash Point(C)

251 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

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