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Key Documents

53379

Sigma-Aldrich

FITC-CM-Dextran

average mol wt 40,000

Synonym(s):

FITC-CM-Dextran 40, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

UNSPSC Code:
12352108
NACRES:
NA.32

biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder or crystals

mol wt

average mol wt 40,000

composition

carboxymethyl content, 3-7%

extent of labeling

0.001-0.020 mol/mol FITC glucose

technique(s)

permeability assay: suitable

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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Application

FITC-CM-Dextran 40, an anionic fluorescent dextran that may be used to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-CM-Dextran 40 may be use to compare its selectivity versus neutral FITC-Dextran 40.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rui Liu et al.
International journal of molecular medicine, 42(5), 2903-2913 (2018-08-23)
Inflammatory bowel disease (IBD) is a multifactorial inflammatory disease, and increasing evidence has demonstrated that the mechanism of the pathogenesis of IBD is associated with intestinal epithelial barrier injury. Long non‑coding RNAs (lncRNAs) are a class of transcripts >200 nucleotides
Reduced diffusion of charge-modified, conformationally intact anionic Ficoll relative to neutral Ficoll across the rat glomerular filtration barrier in vivo.
Axelsson J, Sverrisson K, Rippe A, et al.
American Journal of Physiology: Renal Physiology, 301, F708-F712 (2011)
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Dan Zhang et al.
Journal of cellular physiology, 233(1), 688-698 (2017-03-23)
Understanding the role and underlying regulation mechanism of autophagy in lipopolysaccharide-induced lung injury (LPS-LI) may provide potentially new pharmacological targets for treatment of acute lung injury. The aim of this study was to investigate the functional significance of autophagy in
Chichi Li et al.
Cell death & disease, 10(11), 804-804 (2019-10-28)
Adipose-derived stem cells (ADSCs) have been shown to be beneficial in some pulmonary diseases, and the paracrine effect is the major mechanism underlying ADSC-based therapy. Autophagy plays a crucial role in maintaining stem cell homeostasis and survival. However, the role

Articles

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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