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50020

Sigma-Aldrich

β-Glycerol phosphate disodium salt pentahydrate

≥98.0% (NT)

Synonym(s):

β-GP, β-glycerolphosphate, Disodium β-glycerol phosphate pentahydrate, glycerol-2-phosphate

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About This Item

Empirical Formula (Hill Notation):
C3H7Na2O6P · 5H2O
CAS Number:
13408-09-8
Molecular Weight:
306.11
Beilstein/REAXYS Number:
3744328
EC Number:
212-464-3
MDL number:
MFCD00149083
UNSPSC Code:
41141710
PubChem Substance ID:
57651212
NACRES:
NA.25

Quality Level

200

assay

≥98.0% (NT)

form

solid

impurities

≤2% L-α-glycerol phosphate

loss

26-32% loss on drying

solubility

H2O: 0.1 g/mL, clear, colorless

storage temp.

2-8°C

SMILES string

O.O.O.O.O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

1S/C3H9O6P.2Na.5H2O/c4-1-3(2-5)9-10(6,7)8;;;;;;;/h3-5H,1-2H2,(H2,6,7,8);;;5*1H2/q;2*+1;;;;;/p-2

InChI key

PEMUISUYOHQFQH-UHFFFAOYSA-L

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Application

β-Glycerolphosphate (Glycerol-2-Phosphate) is used in the development of hydrogels and scaffolds that have applications in tissue engineering and cell growth and differentiation.

Biochem/physiol Actions

Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression

Other Notes

Substrate for myo-inositol-1-phosphatase from bovine brain

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Cristiane Machado Mengatto et al.
PloS one, 6(1), e15848-e15848 (2011-01-26)
Successful dental and orthopedic implants require the establishment of an intimate association with bone tissue; however, the mechanistic explanation of how biological systems accomplish osseointegration is still incomplete. We sought to identify critical gene networks involved in osseointegration by exploring
Yung-Hsin Cheng et al.
Tissue engineering. Part A, 16(2), 695-703 (2009-09-23)
Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation. In the study, the gelatin molecules were added to the thermosensitive chitosan/beta-glycerol phosphate (C/GP) disodium salt hydrogels to form chitosan/gelatin/beta-glycerol phosphate (C/G/GP) disodium salt hydrogels which
A Sanghani-Kerai et al.
Bone & joint research, 6(6), 358-365 (2017-06-04)
Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type
Yoshitomo Honda et al.
Scientific reports, 3, 3420-3420 (2013-12-07)
Stem cell-based disease modeling presents unique opportunities for mechanistic elucidation and therapeutic targeting. The stable induction of fate-specific differentiation is an essential prerequisite for stem cell-based strategy. Bone morphogenetic protein 2 (BMP-2) initiates receptor-regulated Smad phosphorylation, leading to the osteogenic
Hideharu Okamoto et al.
PloS one, 7(8), e43800-e43800 (2012-09-01)
BACKGOROUND: MicroRNAs (miRNAs), which regulate biological processes by annealing to the 3'-untranslated region (3'-UTR) of mRNAs to reduce protein synthesis, have been the subject of recent attention as a key regulatory factor in cell differentiation. The effects of some miRNAs
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