PHR1558

Supelco

Pyridine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Pyridine
Empirical Formula (Hill Notation):
C5H5N
CAS Number:
Molecular Weight:
79.10
Beilstein/REAXYS Number:
103233
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

2.72 (vs air)

vapor pressure

10 mmHg ( 13.2 °C)
20 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

899 °F

expl. lim.

12.4 %

packaging

ampule of 3x1.2 mL each

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.509 (lit.)

bp

115 °C (lit.)

mp

−42 °C (lit.)

density

0.978 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1601747

SMILES string

C1=CN=CC=C1

InChI

1S/C5H5N/c1-2-4-6-5-3-1/h1-5H

InChI key

JUJWROOIHBZHMG-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pyridine is a heterocyclic aromatic compound that is a commonly used solvent in organic and inorganic chemistry. Its weakly basic nature allows it to act as a proton acceptor in acid base reactions, and to form salts with strong acids. In the acylation of alcohols, pyridine can act as a nucleophilic catalyst.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0263 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

FlameExclamation mark

Signal Word

Danger

hazcat

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 2

Flash Point(F)

68.0 °F - closed cup

Flash Point(C)

20 °C - closed cup

Certificate of Analysis

Certificate of Origin

Maria Milina et al.
Angewandte Chemie (International ed. in English), 54(5), 1591-1594 (2014-11-08)
Without techniques sensitive to complex pore architectures, synthetic efforts to enhance molecular transport in zeolite and other porous materials through hierarchical structuring lack descriptors for their rational design. The power of positron annihilation lifetime spectroscopy (PALS) to characterize the pore...
Jerri M Rook et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 755-765 (2014-09-23)
Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5) have exciting potential as therapeutic agents for multiple brain disorders. Translational studies with mGlu5 modulators have relied on mGlu5 allosteric site positron emission tomography (PET) radioligands to assess receptor occupancy...
Zhi-xue Cheng et al.
Fish & shellfish immunology, 40(2), 524-530 (2014-08-15)
Streptococcus iniae infection has emerged as a serious fish health and economic problem in the global aquaculture operations. Current antibiotic options are few and possess severe practical limitations and potential adverse environmental impacts. The major factor contributing to the large...
Thomas B Kakule et al.
Journal of the American Chemical Society, 136(51), 17882-17890 (2014-12-02)
The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within PKS-based pathways where the PKS is fused to a single module...
Kai Lun Chang et al.
PloS one, 9(8), e104621-e104621 (2014-08-08)
Findings from epidemiology, preclinical and clinical studies indicate that consumption of coffee could have beneficial effects against dementia and Alzheimer's disease (AD). The benefits appear to come from caffeinated coffee, but not decaffeinated coffee or pure caffeine itself. Therefore, the...
Protocols
GC Analysis of Class 2 Residual Solvents on OVI-G43
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-Cymene; 2,5-Dimethylpyrrole; Acetoin, ≥96%, FCC, FG; 2,5-Dimethylpyrazine; 2,6-Dimethylpyrazine; 2-Ethylpyrazine, ≥98%, FG; 2,3-Dimethylpyrazine; 4-Heptanone; 3-Ethylpyridine; 2,3,5-Trimethylpyrazine; Furfural; Pyrrole; Furfuryl acetate; Linalool; Linalyl acetate; 5-Methylfurfural; γ-Butyrolactone; 2-Acetyl-1-methylpyrrole; Furfuryl alcohol; 2-Acetylpyrrole; Pyrrole-2-carboxaldehyde
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US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
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