PHR1372

Methanol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Methanol, Methyl alcohol
• Linear Formula: CH₃OH
• CAS Number: 67-56-1
• Molecular Weight: 32.04
• Beilstein: 1098229
• EC Number: 200-659-6
• MDL number: MFCD00004595
• PubChem Substance ID: 329823350
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1424109
• vapor density: 1.11 (vs air)
• vapor pressure: 410 mmHg ( 50 °C); 97.68 mmHg ( 20 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 725 °F
• expl. lim.: 36 %
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.329 (lit.)
• bp: 64.7 °C (lit.)
• mp: −98 °C (lit.)
• density: 0.791 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CO
• InChI: 1S/CH4O/c1-2/h2H,1H3
• InChI key: OKKJLVBELUTLKV-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methanol is a widely used polar organic solvent in chemistry, biochemistry, and molecular biology. It is a common solvent in HPLC and mass spectrometry (MS) of small molecules and of biomolecules such as oligonucleotides and proteins. Methanol is also utilized in high performance capillary electrophoresis. Industrial applications of methanol include the manufacture of formaldehyde and methyl esters of organic and inorganic acids. Methanol is used as a solvent and solvent adjuvant for polymers, and as a softening agent for pyroxylin plastics.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7353 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup