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PHR1346

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Methylsulfonylmethane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Dimethyl sulfone, Methyl sulfone

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About This Item

Linear Formula:
(CH3)2SO2
CAS Number:
67-71-0
Molecular Weight:
94.13
Beilstein/REAXYS Number:
1737717
EC Number:
200-665-9
MDL number:
MFCD00007566
UNSPSC Code:
41116107
PubChem Substance ID:
329823331
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1437600

API family

methylsulfonylmethane

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

238 °C (lit.)

mp

107-109 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CS(C)(=O)=O

InChI

1S/C2H6O2S/c1-5(2,3)4/h1-2H3

InChI key

HHVIBTZHLRERCL-UHFFFAOYSA-N

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General description

Methylsulfonylmethane is the oxidized form of dimethyl sulfoxide, generally occurring in green plants, fruits and vegetables. Methylsulfonylmethane can find applications as a solvent to dissolve a wide range of solutes and is also generally used for high temperature reactions. It exhibits pharmacological properties and is reported to reduce peripheral pain, inflammation and arthritis condition.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3469 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC3469
LRAA9140
LRAA1098

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Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee
Brien S, et al.
Evidence-Based Complementary and Alternative Medicine (2011)
Methylsulfonylmethane (MSM). Monograph.
Alternative medicine review : a journal of clinical therapeutic, 8(4), 438-441 (2003-12-05)
Jacob F Smith et al.
Frontiers in physiology, 11, 80-80 (2020-03-07)
Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative
S Brien et al.
Osteoarthritis and cartilage, 16(11), 1277-1288 (2008-04-18)
Conventional treatment of osteoarthritis (OA) with non-steroidal anti-inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cyclo-oxygenase-2 inhibitors, identifying safer alternative treatment options is needed. The objective of this systematic review
Youn Hee Joung et al.
International journal of oncology, 44(3), 883-895 (2014-01-10)
Human urinary bladder cancer is the fifth most common cancer, with a worldwide estimate of about two million patients. Recurrence after complete transurethral prostatic resection is the most important problem in therapy. Combination therapy is a new approach in the

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