All Photos(9)

O8001

Sigma-Aldrich

Octyl β-D-glucopyranoside

≥98% (GC)

Synonym(s):
n-Octyl glucoside, OGP
Empirical Formula (Hill Notation):
C14H28O6
CAS Number:
Molecular Weight:
292.37
Beilstein:
84118
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

description

non-ionic

assay

≥98% (GC)

mol wt

micellar avg mol wt 25,000

aggregation number

84

CMC

20-25 mM (20-25°C)

transition temp

cloud point >100 °C

storage temp.

−20°C

SMILES string

CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C14H28O6/c1-2-3-4-5-6-7-8-19-14-13(18)12(17)11(16)10(9-15)20-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1

InChI key

HEGSGKPQLMEBJL-RKQHYHRCSA-N

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Application

Octyl β --D-glucopyranoside has been used:
  • In varying concentrations to wash Sepharose beads to study the interaction of Albumin-shFcRn in the presence of Octyl β-D-glucopyranoside
  • As a lysis and solubilization solution for bacterial lipoprotein preparation
  • To solubilize the recombinant 47 kDa antigen from E. coli cell
  • As a component of lysis buffer for determination of protein content by BCA assay
  • In deglycolysation process
  • As a component of lysis buffer to prepare mitochondrial extracts
Non-ionic, dialyzable detergent for the solubilization and isolation of membrane proteins. Has been shown to increase the resolution of proteins in 2D gels.

Packaging

100, 250, 500 mg in poly bottle
1, 5, 10, 25, 100 g in poly bottle

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

IL-10 Prevents apoptosis of brain endothelium during bacteremia.
Londo?o D, et al.
Journal of Immunology, 1100060-1100060 (2011)
Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo.
Samovski D, et al.
The Journal of Biological Chemistry, 285(10), 6879-6890 (2010)
The major histocompatibility complex?related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.
The Journal of Experimental Medicine, 197(3), 315-322 (2003)
Genetic and physicochemical characterization of the recombinant DNA-derived 47-kilodalton surface immunogen of Treponema pallidum subsp. pallidum.
Chamberlain N R, et al.
Infection and Immunity, 56(1), 71-78 (1988)
Insulin and AMPK regulate fatty acid translocase/CD36 plasma membrane recruitment in cardiomyocytes via RabGAP AS160 and Rab8a Rab GTPase.
Journal of Lipid Research, jlr-M023424 (2012)

Protocols

Solubilization of Membrane Proteins

This page shows how to solubilize membrane proteins with products from GE Healthcare.

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