NIST911C

Cholesterol

NIST^® SRM^® 911c

• Synonym(s): 3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
• Empirical Formula (Hill Notation): C₂₇H₄₆O
• CAS Number: 57-88-5
• Molecular Weight: 386.65
• Beilstein/REAXYS Number: 1915888
• MDL number: MFCD00003646
• UNSPSC Code: 41116107
• PubChem Substance ID: 329818776
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 100
• packaging: pkg of 2 g
• manufacturer/tradename: NIST^®
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.)
• density: 1.067 g/mL at 25 °C (lit.)
• application(s): clinical research; clinical testing
• format: neat
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: HVYWMOMLDIMFJA-DPAQBDIFSA-N

Description

General description

This Standard Reference Material (SRM) is certified as a chemical of known purity. It is intended primarily for use in the calibration and standardization of procedures for the determination of cholesterol in research samples and for routine evaluations of daily working standards used in these procedures. A unit of SRM 911c consists of 2 g of material. For more information, please refer to the SDS and COA.

SRM 911C_cert

SRM 911C_SDS

Application

• Estrone-mediated Improvements in Endothelial Function: Recent research has demonstrated how estrone treatment can lower ROS and NOX4 levels, significantly improving endothelial function in ovariectomized Wistar rats. This study utilized cholesterol as a critical component in understanding hormonal effects on vascular health, providing valuable insights for cardiovascular disease treatment strategies (Oliveira et al., 2024).


• Nephrotic Syndrome Case Study in Polycythemia Vera: Cholesterol plays a significant role in a case study of IgA nephropathy presenting as nephrotic syndrome in polycythemia vera. This research underscores the importance of cholesterol management in complex clinical scenarios, enhancing our understanding of kidney diseases linked with abnormal cholesterol metabolism (Rajasekar et al., 2024).


• Community Health Impact over a Decade: An extensive study over ten years has reviewed men′s health events in a socioeconomically diverse U.S. city, analyzing the impact of community-based interventions on health outcomes where cholesterol management was a key focus. The findings contribute to public health strategies aimed at improving population-wide cardiovascular health (Tinsley et al., 2024).


• Familial Hypercholesterolemia Complexities: A detailed case study addresses the complexities of managing familial hypercholesterolemia, discussing diagnostic and therapeutic approaches. The study highlights cholesterol′s central role in developing treatment protocols that can mitigate the risks associated with this genetic disorder (Rasheed et al., 2024).


• Cardiometabolic Markers and Fetal Growth: Research examining the association between maternal cardiometabolic markers, including cholesterol, and fetal growth in non-complicated pregnancies provides insights into prenatal care. The study suggests that managing cholesterol levels could influence fetal development outcomes, emphasizing the importance of maternal health monitoring (Omaña-Guzmán et al., 2024).

Biochem/physiol Actions

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

Other Notes

Certified for the analytes listed below.
Cholestrol

See certificate for values and more details at nist.gov/SRM.

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology

SRM is a registered trademark of National Institute of Standards and Technology

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable