G6257

Sigma-Aldrich

Glutaraldehyde solution

Grade II, 25% in H2O

Synonym(s):
Pentane-1,5-dial, Glutaric dialdehyde solution
Linear Formula:
OHC(CH2)3CHO
CAS Number:
Molecular Weight:
100.12
Beilstein/REAXYS Number:
605390
MDL number:
PubChem Substance ID:
NACRES:
NA.21

type

Grade II

Quality Level

concentration

25% in H2O

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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Application

Glutaraldehyde solution has been used:
  • for fixation of mouse and esophageal cancer cell lines
  • to crosslink amyloid-β protein
  • to crosslink gelatin in 3D scaffold preparation of trachea

Packaging

1 L in glass bottle
100 mL in glass bottle
Not refrigerated en route

Biochem/physiol Actions

Glutaraldehyde is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry. It exists in different forms under acidic or neutral conditions. It is a biocide widely used as a disinfectant in hospitals and industries and is toxic to aquatic organisms. Its allergic nature leads to hypersensitivity reactions. Contact of glutaraldehyde vapors in endoscopy contributes to Colitis.

Caution

This grade is not recommended for use as an electron microscopy fixative.

Preparation Note

Not specially purified.

Signal Word

Danger

Target Organs

Respiratory system

Supp Hazards

EUH071

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN3265 - class 8 - PG 2 - EHS - Corrosive liquid, acidic, organic, n.o.s., HI: all

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin
Du XX, et al.
Biomedicine and Pharmacotherapy, 67(5), 417-424 (2013)
Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking
Migneault I, et al.
Biotechniques, 37(5), 790-802 (2004)
Sorption characteristics of mixed molecules of glutaraldehyde from water on mesoporous acid-amine modified low-cost activated carbon: mechanism, isotherm, and kinetics
Lloyd M, et al.
Journal of Chemistry, 2015, 790-802 (2015)
Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls
Esparza TJ, et al.
Annals of Neurology, 73(1), 104-119 (2013)
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
Repetto G, et al.
Nature Protocols, 3(7), 1125-1125 (2008)

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