G7776

Sigma-Aldrich

Glutaraldehyde solution

Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

Synonym(s):
Pentane-1,5-dial, Glutaric dialdehyde solution
Linear Formula:
OHC(CH2)3CHO
CAS Number:
Molecular Weight:
100.12
Beilstein/REAXYS Number:
605390
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

type

Grade I

concentration

70% in H2O

application(s)

electron microscopy: suitable (fixative)

storage temp.

−20°C

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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General description

Glutaraldehyde is a fixative used in electron microscopy. It is a rapidly penetrating fixative and an alternative to the expensive and toxic buffered osmium tetroxide. Glutaraldehyde contains two aldehyde group separated by three methylene bridges. It mediates protein crosslinking at their amino groups.

Application

Glutaraldehyde solution has been used as a fixative for transfected adherent monkey kidney fibroblasts (COS-7) cells for electron microscopy studies, human osteosarcoma (U2OS) cells for super-resolution (SR) experiments and for hydrogels for scanning electron microscopy (SEM) studies.

Packaging

10 mL in glass bottle

Signal Word

Danger

Target Organs

Respiratory system

Supp Hazards

EUH071

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN2922 - class 8 - PG 2 - EHS - acidic - Corrosive liquids, toxic, n.o.s., HI: all

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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D?Alessandro G, et al.
Nature Communications, 9(1), 5376-5376 (2018)
Poly (Ethylene Glycol)-Crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior
Su J, et al.
Biomaterials, 201(1), 99-112 (2019)
Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do
Kiernan JA
Microscopy today, 8(1), 8-13 (2000)
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy
Schessl J, et al.
The Journal of Clinical Investigation, 118(3), 904-912 (2008)
Ning Yang et al.
Development (Cambridge, England), 142(12), 2194-2202 (2015-05-30)
Hair follicle morphogenesis requires precisely controlled reciprocal communications, including hedgehog (Hh) signaling. Activation of the Hh signaling pathway relies on the primary cilium. Disrupting ciliogenesis results in hair follicle morphogenesis defects due to attenuated Hh signaling; however, the loss of...

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