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F6377

Sigma-Aldrich

Fluorescein sodium salt

used as fluorescent tracer

Synonym(s):
Sodium fluorescein, NaFl, Uranine, NaFluo, Acid Yellow 73, D&C;Yellow No. 8
Empirical Formula (Hill Notation):
C20H10Na2O5
CAS Number:
Molecular Weight:
376.27
Colour Index Number:
45350
Beilstein:
3833041
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

form

powder

application(s)

hematology: suitable
histology: suitable

pH

8.3 (20 °C, 10 g/L)

mp

>300 °C

solubility

H2O: 1 mg/mL

fluorescence

λex 460 nm; λem 515 nm(lit.)

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2

InChI key

RGPLGPBQJOQFJS-UHFFFAOYSA-L

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General description

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Application

Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).
Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.

Packaging

100, 500 g in glass bottle

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

423.7 °F - Pensky-Martens closed cup

Flash Point(C)

217.6 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Structural mechanisms of acute VEGF effect on microvessel permeability.
American Journal of Physiology. Heart and Circulatory Physiology, 284, H2124-H2124 (2003)
In vitro model of the outer blood-retina barrier.
Steuer H
Brain Research. Brain Research Protocols, 13, 26-26 (2004)
The determination of the conduction mechanism and optical band gap of fluorescein sodium salt.
Yakuphanoglu F, et al.
Physica B: Condensed Matter, 382(1), 21-25 (2006)
Tom De Bruyn et al.
Journal of pharmaceutical sciences, 100(11), 5018-5030 (2011-08-13)
The aim of this study was to characterize the in vitro hepatic uptake kinetics of sodium fluorescein (NaFluo) and identify the transporters involved. NaFluo exhibited saturable uptake kinetics in suspended rat and human hepatocytes as reflected by K(m) values of...
Electrical conductivity and dielectric relaxation behavior of fluorescein sodium salt (FSS).
Mansour SA, et al.
Solid State Communications, 150(29), 1386-1391 (2010)

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