C0430

(−)-Cotinine solution

drug standard, 1.0 mg/mL in methanol

• EC Number: 200-659-6
• MDL number: MFCD00077696
• PubChem Substance ID: 329774789
• NACRES: NA.24

Properties

• grade: drug standard
• Quality Level: 100
• Agency: EPA 1694
• concentration: 1.0 mg/mL in methanol
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): environmental; pharmaceutical (small molecule)
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: CN1[C@@H](CCC1=O)c2cccnc2
• InChI: 1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
• InChI key: UIKROCXWUNQSPJ-VIFPVBQESA-N
• Gene Information: human ... CYP1A2(1544) , CYP2A6(1548) ; mouse ... Cyp2a5(13087)

Description

General description

(−)-Cotinine is a major metabolite of nicotine, widely used as a biochemical marker for to evaluate the exposure to environmental tobacco smoke, for the validation of abstinence smoking and to determine the percentage of active smoking behavior.

Application

(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS). (−)-Cotinine may be may used as an analytical reference standard for the quantification of the analyte in biological samples using high-performance liquid chromatography technique.

(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H301 + H311 + H331 - H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 51.8 °F - closed cup
• Flash Point(C): 11 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves