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01-6635

Sigma-Aldrich

Arsenic(III) oxide

SAJ first grade, ≥99.0%

Synonym(s):

Arsenic trioxide, Arsenous acid

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About This Item

Empirical Formula (Hill Notation):
As2O3
CAS Number:
1327-53-3
Molecular Weight:
197.84
EC Number:
215-481-4
MDL number:
MFCD00003433
UNSPSC Code:
12352103
PubChem Substance ID:
329747341

grade

SAJ first grade

vapor pressure

0.000001 hPa ( 66 °C)

assay

≥99.0%

form

powder

availability

available only in Japan

SMILES string

O=[As]O[As]=O

InChI

1S/As2O3/c3-1-5-2-4

InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

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Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

target_organs

Respiratory system,Cardio-vascular system,Gastrointestinal tract

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
U2522

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Yanfei Jia et al.
PloS one, 8(1), e54774-e54774 (2013-02-06)
Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC), represented by the production of AFP, has a more aggressive behavior than common gastric cancer. The underlying mechanisms are not well understood. Arsenic trioxide (As(2)O(3)) is used clinically to treat acute promyelocytic leukemia(APL) and has
Liangchun Hao et al.
Journal of pediatric hematology/oncology, 35(2), e67-e70 (2013-02-16)
The aim of this study was to investigate the hepatotoxicity induced by arsenic trioxide (As2O3) at a therapeutic dose for pediatric acute promyelocytic leukemia (APL). A total of APL patients received As2O3 treatment by IV drip. Hepatotoxicity was monitored based
Masamitsu Yanada et al.
Blood, 121(16), 3095-3102 (2013-02-16)
The optimal treatments for relapsed acute promyelocytic leukemia (APL) remain equivocal. We conducted a phase 2 study to evaluate the efficacy and feasibility of a sequential treatment consisting of induction and consolidation with arsenic trioxide (ATO), peripheral blood stem cell
Huihui Wang et al.
Environmental toxicology, 28(5), 267-275 (2013-04-17)
Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. In this manuscript, we investigated 23 APL
Athena Kritharis et al.
Annals of hematology, 92(6), 719-730 (2013-03-16)
For more than 2,000 years, arsenic and its derivatives have shown medical utility. Owing to the toxicities and potential carcinogenicity of arsenicals, their popularity has fluctuated. The exact mechanism of action of therapeutic arsenic is not well characterized but likely
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