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Key Documents

MAB1293

Sigma-Aldrich

Anti-DNA Antibody, double stranded, clone AE-2

clone AE-2, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AE-2, monoclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

isotype

IgG3

shipped in

wet ice

target post-translational modification

unmodified

Specificity

Double stranded DNA. MAB1293 produces a homogeneous staining pattern in the nucleus of normal and malignant cells.

Immunogen

Epitope: double stranded
Nuclei of Raji Burkitt′s lymphoma cells

Application

Anti-DNA Antibody, double stranded, clone AE-2 is a high quality Mouse Monoclonal Antibody for the detection of DNA & has been validated in ICC & IHC.
Immunocytochemistry: paraformaldehyde fixed cell preparations

Immunohistochemistry: paraformaldehyde fixed frozen tissue sections

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected double stranded DNA in human prostrate and tonsil tissue sections.

Optimal working dilutions must be determined by the end user.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25 NaCl and 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Analysis Note

Control
POSITIVE CONTROL: Human tonsil

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Manuel Adrian Suter et al.
Scientific reports, 11(1), 7243-7243 (2021-04-02)
Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING
Yang Liu et al.
Scientific reports, 6, 18696-18696 (2016-01-05)
Iridovirid infection is associated with the catastrophic loss in aquaculture industry and the population decline of wild amphibians and reptiles, but none of the iridovirid life cycles have been well explored. Here, we report the detailed visualization of the life
Weiwei Wang et al.
Molecular cancer research : MCR, 20(7), 1137-1150 (2022-03-30)
Targeting the DNA damage response in combination with radiation enhances type I interferon (T1IFN)-driven innate immune signaling. It is not understood, however, whether DNA-dependent protein kinase (DNA-PK), the kinase critical for repairing the majority of radiation-induced DNA double-strand breaks in
B De Paepe et al.
Journal of clinical pathology, 62(2), 172-176 (2009-02-03)
Mitochondrial diseases display a heterogeneous spectrum of clinical phenotypes and therefore the identification of the underlying gene defect is often a difficult task. To develop an immunohistochemical approach to stain skeletal muscle for the five multi-protein complexes that organise the
Lateral elements inside synaptonemal complex-like polycomplexes in ndt80 mutants of yeast bind DNA.
Bhuiyan, H; Dahlfors, G; Schmekel, K
Genetics null

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