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Key Documents

ABF219

Sigma-Aldrich

Anti-SARM Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein, Sterile alpha motif domain-containing protein 2, SAM domain-containing protein 2, Tir-1 homolog

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SARM1(23098)

General description

Sterile alpha and Armadillo repeat protein (SARM), also known as Sterile alpha and TIR motif-containing protein 1 (SARM1) and Sterile alpha motif domain-containing protein 2 (SAMD2), is involved in the innate immnune response. SARM blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. SARM is expressed kidney and liver with lower levels found in placenta.

Specificity

This antibody recognizes the C-terminus of SARM.

Immunogen

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human SARM.

Application

Detect Sterile alpha & Armadillo repeat protein using this rabbit polyclonal antibody, Anti-SARM Antibody validated for use in western blotting, ICC & Immunofluorescence.
Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected SARM in Daudi cells.

Immunofluorescence Analysis: 2 µg/mL from a representative lot detected SARM in Daudi cells.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Quality

Evaluated by Western Blotting in Daudi cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected SARM in 15 µg of Daudi cell lysate.

Target description

~89 kDa observed. Uncharacterized bands may appear in some lysates.

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Daudi cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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