MilliporeSigma
All Photos(1)

5.31042

Sigma-Aldrich

Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem

A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

Synonym(s):
Estrogen Receptor Antagonist, ICI 182,780 - CAS 129453-61-8 - Calbiochem, GPR30 Agonist, ICI 182,780, ICI 182780, ICI182780
Empirical Formula (Hill Notation):
C32H47F5O3S
CAS Number:
Molecular Weight:
606.77
MDL number:

assay

≥98% (HPLC)

Quality Level

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

InChI

1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1

InChI key

VWUXBMIQPBEWFH-WCCTWKNTSA-N

General description

A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable estradiol derivative that acts as an estrogen antagonist and down-regulates estrogen receptors without affecting estrogen receptor-mediated progesterone receptor expression. Hence, it lacks estrogen agonist activity. Shown to be more effective than tamoxifen in reducing estrogen receptors in breast tumor cells. Suppresses the growth of MCF-7 xenografts in mice for twice as long as tamoxifen and delays tumor growth.



Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable estrogen antagonist. More effective than tamoxifen in reducing estrogen receptors in breast tumor cells.

Packaging

10 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ER
Secondary Target
GPR30

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wakeling, A. E., et al. 1991. Cancer Res.51, 3867.
Dauvois, S., et al. 1993. J. Cell. Sci.106, 1377.
Howell, A., et al. 1995. The Lancet.8941, 29.
Robertson, J.F., et al. 2001. J. Steroid Biochem. Mol Biol.79, 209.

Legal Information

Sold with the permission of AstraZeneca UK. Limited for research purposes only.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Quality

Enter Lot Number to search for Certificate of Quality (COQ).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service