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438190

Sigma-Aldrich

Anti-LRP, Heavy Chain Mouse mAb (8G1)

liquid, clone 8G1, Calbiochem®

Synonym(s):

Anti-Low Density Lipoprotein Receptor-Related Protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

8G1, monoclonal

form

liquid

does not contain

preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRP1(4035)

General description

Purified mouse monoclonal antibody. Recognizes the ~515 kDa LRP heavy chain protein.
Recognizes the ~515 kDa LRP heavy chain protein.
This Anti-LRP, Heavy Chain Mouse mAb (8G1) is validated for use in ELISA, FC, Immunoblotting, IP, Paraffin Sections, Neutralization Studies for the detection of LRP, Heavy Chain.

Immunogen

Human
native LRP from human placenta

Application

ELISA (see comments)

Flow Cytometry (see comments)

Immunoblotting (1-5 µg/ml)

Immunoprecipitation (see comments)

Paraffin Sections (1-10 µg/ml)

Neutralization Studies (see comments)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 50 mM phosphate buffer, pH 7.4.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Mikhailenko, I., et al. 2001. J. Biol. Chem.276, 39484.
Rebeck, W.G., et al. 2001. Mol. Brain Res.87, 238.
Strickland, D.K., et al. 1990. J. Biol. Chem.265, 17401.
Recognizes the low density heavy chain (~515 kDa) by immunoblotting under non-reducing conditions. This antibody has also been reported to work for immunoprecipitation, flow cytometry, and ELISA. Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abhay P Sagare et al.
Journal of Alzheimer's disease : JAD, 24(1), 25-34 (2010-12-16)
Soluble circulating low density lipoprotein receptor-related protein-1 (sLRP) provides key plasma binding activity for Alzheimer's disease (AD) amyloid-β peptide (Aβ). sLRP normally binds 70-90% of plasma Aβ preventing free Aβ access to the brain. In AD, Aβ binding to sLRP
Albin Jeanne et al.
Oncotarget, 6(20), 17981-18000 (2015-06-06)
The multi-modular glycoprotein thrombospondin-1 (TSP-1) is considered as a key actor within the tumor microenvironment. Besides, TSP-1 binding to CD47 is widely reported to regulate cardiovascular function as it promotes vasoconstriction and angiogenesis limitation. Therefore, many studies focused on targeting

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