14-626-M
EGFR (L858R) Protein, active, 10 µg
Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R, for use in Enzyme Assays.
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32
Recommended Products
biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
mol wt
Mw 85.8 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable
NCBI accession no.
UniProt accession no.
General description
N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R
Quality
routinely evaluated by phosphorylation of 0.1mg/ml Poly (Glu4-Tyr)
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Certificates of Analysis (COA)
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Thomas J Lynch et al.
The New England journal of medicine, 350(21), 2129-2139 (2004-05-01)
Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms
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