1.08432

Urea

crystalline, EMPROVE^® API, Ph. Eur., BP, USP

• Synonym(s): Carbamide, Carbonyl diamide, Carbonyldiamine, Diaminomethanone, Carbonyldiamide
• Linear Formula: NH₂CONH₂
• CAS Number: 57-13-6
• Molecular Weight: 60.06
• Beilstein/REAXYS Number: 635724
• MDL number: MFCD00008022
• EC Index Number: 200-315-5

Properties

• biological source: synthetic
• Quality Level: 600
• grade: GMO free; GMP; Halal; Kosher
• agency: BP; Ph. Eur.; USP
• product line: EMPROVE^® API
• form: crystalline
• impurities: low in endotoxins
• mp: 132-135 °C (lit.)
• density: 1.335 g/mL at 25 °C (lit.)
• application(s): ophthalmics; pharmaceutical; semi-solid formulation
• foreign activity: Aflatoxin free
• storage temp.: 2-25°C
• SMILES string: NC(N)=O
• InChI: 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
• InChI key: XSQUKJJJFZCRTK-UHFFFAOYSA-N

Description

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Urea as an active pharmaceutical ingedient is used mainly in dermatology for cremes and ointments and for ophthalmic applications. Urea crystalline Emprove^® API is manufactured under ICH Q7. A CEP and an US-DMF is available.

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Packaging

1.08432.0001 // 3x 1kg // PE bottle
1.08432.1000 // 1kg // PE bottle
1.08432.5000 // 5kg // PE bottle
1.08432.9029 // 25 kg //Double PE bag

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable