1.37004

Titriplex^® III

(ethylene dinitrilo tetraacetic acid disodium salt dihydrate), EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonym(s): Ethylenediaminetetraacetic acid disodium salt dihydrate, Disodium dihydrogen ethylenediaminetetraacetate, Ethylenediaminetetraacetic acid disodium salt, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂Na₂O₈ · 2H₂O
• CAS Number: 6381-92-6
• Molecular Weight: 372.24
• Beilstein/REAXYS Number: 3900609
• UNSPSC Code: 12352107
• EC Index Number: 205-358-3

Properties

• grade: ACS reagent
• Quality Level: 500
• agency: BP; ChP; JP; Ph. Eur.; USP
• product line: EMPROVE^® EXPERT
• form: solid
• feature: RNase and DNase free
• pH: 4-5 (20 °C, 50 g/L in H₂O)
• mp: 248 °C (dec.) (lit.)
• application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• storage temp.: no temp limit
• SMILES string: O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
• InChI key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Titriplex^® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics and can enhance the function of preservatives. The disodium salt provides improved solubility in water compared to standard EDTA.
Due to its low microbial and endotoxin limits, Titriplex^® III (ethylene dinitrilo tetraacetic acid disodium salt dihydrate) Emprove^® Expert is especially suitable for high-risk applications.

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Other Notes

Elimination of water of crystallization: 110 °C

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Titriplex is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H332,H373
• pcodes: P260 - P271 - P304 + P340 + P312 - P314 - P501
• Hazard Classifications: Acute Tox. 4 Inhalation - STOT RE 2 Inhalation
• target_organs: Respiratory Tract
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable