1.02931

Dimethyl sulfoxide

for DNA and peptide synthesis (max. 0.025% H₂O)

• Synonym(s): Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO, DMSO
• Linear Formula: (CH₃)₂SO
• CAS Number: 67-68-5
• Molecular Weight: 78.13
• Beilstein/REAXYS Number: 506008
• MDL number: MFCD00002089
• UNSPSC Code: 12191502
• EC Index Number: 200-664-3
• NACRES: NA.05

Properties

• vapor density: 2.7 (vs air)
• Quality Level: 200
• vapor pressure: 0.42 mmHg ( 20 °C)
• assay: ≥99.9% (GC)
• form: liquid
• autoignition temp.: 573 °F
• potency: 28300 mg/kg LD₅₀, oral (Rat); 40000 mg/kg LD₅₀, skin (Rat)
• expl. lim.: 42 %, 63 °F
• technique(s): DNA amplification: suitable
• impurities: ≤0.0002 meq/g Alkalinity; ≤0.0005 meq/g Acidity; ≤0.025% Water
• evapn. residue: ≤10 mg/L
• color: APHA: ≤10
• refractive index: n20/D 1.479 (lit.)
• kinematic viscosity: 2.14 cSt
• bp: 189 °C (lit.)
• mp: 16-19 °C (lit.)
• transition temp: flash point 87 °C
• solubility: 1000 g/L
• density: 1.10 g/mL (lit.)
• application(s): peptide synthesis
• storage temp.: 2-30°C
• SMILES string: CS(C)=O
• InChI: 1S/C2H6OS/c1-4(2)3/h1-2H3
• InChI key: IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Description

Application

• Dimethyl sulfoxide as a gas phase charge-reducing agent for the determination of PEGylated proteins′ intact mass.: This study explores the effectiveness of DMSO in reducing the charge of proteins during mass spectrometry, improving the accuracy of mass measurements for PEGylated proteins, a critical aspect in biopharmaceutical analyses (Skjærvø Ø et al., 2024).


• Benzoselenadiazole-Functionalized H-Bonded Arylamide Foldamers: Solvent-Responsive Properties and Helix Self-Assembly Directed by Chalcogen Bonding in Solid State.: This paper discusses the role of DMSO in influencing the self-assembly properties of novel foldamers, showcasing its importance in the study of advanced material sciences (Liu CZ et al., 2024).


• Controlling Interfacial Hydrogen Bonding at a Gold Surface: The Effect of Organic Cosolvents.: This study presents DMSO′s role in modulating hydrogen bonding at interfaces, particularly in the presence of gold surfaces, which is relevant in surface chemistry and sensor applications (Al-Mualem ZA et al., 2024).

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Specifications

Saturation Concentration in Air: 8.0 g/m3 (20 °C)

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Color: ≤ 10 Hazen
Acidity: ≤ 0.0005 meq/g
Alkalinity: ≤ 0.0002 meq/g
Evaporation residue: ≤ 10 mg/l
Water: ≤ 0.025 %

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup