MilliporeSigma
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1.02408

Supelco

Tris(hydroxymethyl)aminomethane

volumetric standard, secondary reference material for acidimetry, traceable to NIST Standard Reference Material (SRM) Certipur® Reag. Ph Eur,Reag. USP

Synonym(s):
2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol
Linear Formula:
NH2C(CH2OH)3
CAS Number:
Molecular Weight:
121.14
Beilstein:
741883
MDL number:
EC Index Number:
201-064-4

Agency

ISO 17025
reag. Ph. Eur.
reag. USP

Quality Level

vapor pressure

0.0267 hPa ( 20 °C)

form

solid

potency

>5000 mg/kg LD50, oral (Rat)
>5000 mg/kg LD50, skin (Rat)

technique(s)

titration: suitable

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

solubility

678 g/L

density

1.35 g/cm3 at 23 °C

bulk density

840 kg/m3

storage temp.

15-25°C

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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This Item
1.083822528591.08307
technique(s)

titration: suitable

technique(s)

-

technique(s)

-

technique(s)

-

agency

ISO 17025

agency

reag. Ph. Eur.

agency

-

agency

BP, ChP, JPC, Ph. Eur., USP

vapor pressure

0.0267 hPa ( 20 °C)

vapor pressure

0.0267 hPa ( 20 °C)

vapor pressure

-

vapor pressure

0.0267 hPa ( 20 °C)

form

solid

form

solid

form

crystalline

form

solid

potency

>5000 mg/kg LD50, oral (Rat)

potency

>5000 mg/kg LD50, oral (Rat), >5000 mg/kg LD50, skin (Rat)

potency

-

potency

-

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

-

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

General description

Tris(hydroxymethyl)aminomethane is a volumetric standard manufactured under rigorous conditions and measured with the highest possible precision. Its mass fraction is determined by potentiometric titration, and it is qualified in a DIN EN ISO/IEC 17025 accredited laboratory.

Please visit ISO certificates and Site Quality Self-Assessments to access the current certificates of accreditation.

Download your certificate at http://www.sigma-aldrich.com to view certified values, including uncertainty and expiry date.

Application

It finds its use as a certified reference material (CRM) for the standardization of volumetric solutions in acidimetric titrations, according to USP and Ph. Eur.

Features and Benefits

  • Available as a solid in a secure glass bottle to ensure its stability for the entire shelf life until opened.
  • Certified reference material according to ISO 17034
  • High-purity material traceable to NIST SRMs
  • Qualified in a DIN EN ISO/IEC 17025 accredited laboratory
  • In accordance with the chapter reagents of USP and Ph. Eur
  • High-quality offering accurate titer determinations
  • Accompanied by a certificate of analysis (CoA)

Packaging

SKU-pack size numbers ending with a "3" are SmartChemicals with an RFID tag on the label for seamless data transfer to the instrument, e.g. xxxxxx1003 or xxxxxxx 4003. More information on www.sigmaaldrich.com/SmartChemicals

Legal Information

CERTIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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