1.02408

Tris(hydroxymethyl)aminomethane

volumetric standard, secondary reference material for acidimetry, traceable to NIST Standard Reference Material (SRM) Certipur^® Reag. Ph Eur,Reag. USP

• Synonym(s): Tris base, Trometamol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM
• Linear Formula: NH₂C(CH₂OH)₃
• CAS Number: 77-86-1
• Molecular Weight: 121.14
• Beilstein: 741883
• MDL number: MFCD00004679
• EC Index Number: 201-064-4

Properties

• Quality Level: 300
• Agency: ISO 17025; reag. Ph. Eur.; reag. USP
• vapor pressure: 0.0267 hPa ( 20 °C)
• form: solid
• potency: >5000 mg/kg LD₅₀, oral (Rat); >5000 mg/kg LD₅₀, skin (Rat)
• technique(s): titration: suitable
• pH: 10.2-10.6 (20 °C, 6 g/L in H₂O)
• useful pH range: 7-9
• pKa (25 °C): 8.1
• bp: 219-220 °C/10 mmHg (lit.); 219-220 °C/13.3 hPa
• mp: 167-172 °C (lit.)
• solubility: 678 g/L
• density: 1.35 g/cm³ at 23 °C
• bulk density: 840 kg/m³
• storage temp.: 15-25°C
• SMILES string: NC(CO)(CO)CO
• InChI: 1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
• InChI key: LENZDBCJOHFCAS-UHFFFAOYSA-N

Description

General description

Tris(hydroxymethyl)aminomethane is a volumetric standard manufactured under rigorous conditions and measured with the highest possible precision. Its mass fraction is determined by potentiometric titration, and it is qualified in a DIN EN ISO/IEC 17025 accredited laboratory.

Application

It finds its use as a certified reference material (CRM) for the standardization of volumetric solutions in acidimetric titrations, according to USP and Ph. Eur.

Features and Benefits

• Available as a solid in a secure glass bottle to ensure its stability for the entire shelf life until opened.
• Certified reference material according to ISO 17034
• High-purity material traceable to NIST SRMs
• Qualified in a DIN EN ISO/IEC 17025 accredited laboratory
• In accordance with the chapter reagents of USP and Ph. Eur
• High-quality offering accurate titer determinations
• Accompanied by a certificate of analysis (CoA)

Packaging

SKU-pack size numbers ending with a "3" are SmartChemicals with an RFID tag on the label for seamless data transfer to the instrument, e.g. xxxxxx1003 or xxxxxxx 4003. More information on www.sigmaaldrich.com/SmartChemicals

Legal Information

CERTIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable