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Key Documents

07-1813

Sigma-Aldrich

Anti-Septin-2 Antibody

serum, from rabbit

Synonym(s):

Neural precursor cell expressed developmentally down-regulated protein 5, neural precursor cell expressed, developmentally down-regulated 5, septin 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
western blot: suitable

NCBI accession no.

NP_004395.1

UniProt accession no.

Q15019

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SEPTIN2(4735)

General description

Septin-2 belongs to the septin family of GTPases. Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septin-2 is expressed in the brain and may be associated with Alzheimer′s disease.

Specificity

This antibody recognizes Septin-2.

Immunogen

Epitope: Unknown
His-tagged recombinant protein corresponding to human Septin-2.

Application

Immunofluorescence: Reported by external laboratory using representative lot.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Cell Cycle, DNA Replication & Repair
Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.

Quality

Evaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected Septin-2 on 10 µg of Hek293 cell lysate.

Target description

41 kDa

Physical form

Unpurified
Unpurified rabbit polyclonal with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
Hek293 cell lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kerrie B Collins et al.
The Journal of cell biology, 219(2) (2019-12-23)
Podosomes are compartmentalized actin-rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matrix. Matrix remodeling by endothelial podosomes facilitates invasion and thereby vessel formation. However, the mechanisms underlying endothelial podosome formation and function remain unclear. Here

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