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Key Documents

06-272

Sigma-Aldrich

Anti-JAK1 Antibody

serum, Upstate®

Synonym(s):

Anti-AIIDE, Anti-JAK1B, Anti-JTK3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, hamster, mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_002227

UniProt accession no.

P23458

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... JAK1(3716)

Specificity

JAK1

Immunogen

HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)

Application

Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Immunological Signaling

Quality

routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus

Target description

130 kDa

Physical form

Antiserum
whole rabbit antiserum containing 0.05% sodium azide

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Tortolani, P J, et al.
Blood, 85, 3444-3451 (1995)
N I Obiri et al.
The Journal of biological chemistry, 272(32), 20251-20258 (1997-08-08)
Interleukin (IL)-13 and IL-4 are cytokine products of TH2 cells which exert similar effects in a variety of cell types. We recently described IL-13R expression on human renal cell and colon carcinoma cells and demonstrated that gammac is not a
Erythropoietin and interleukin-2 activate distinct JAK kinase family members.
Barber, DL; D'Andrea, AD
Molecular and cellular biology null
Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component.
Robledo, O, et al.
The Journal of Biological Chemistry, 272, 4855-4863 (1997)
P Auguste et al.
The Journal of biological chemistry, 272(25), 15760-15764 (1997-06-20)
Oncostatin M (OSM) mediates its bioactivities through two different heterodimer receptors. They both involve the gp130-transducing receptor, which dimerizes with either leukemia inhibitory receptor beta or with OSM receptor beta (OSMRbeta) to generate, respectively, type I and type II OSM
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