04-1573
Anti-Ataxin-7 Antibody, clone 3SCA-1C1
ascites fluid, clone 3SCA-1C1, from mouse
Synonym(s):
ADCAII, OPCA3, SCA7
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
ascites fluid
antibody product type
primary antibodies
clone
3SCA-1C1, monoclonal
species reactivity
rat, mouse
species reactivity (predicted by homology)
human (immunogen homology)
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... ATXN7(6314)
General description
Ataxin-7 is a protein of unknown function. However, since this protein contains a nuclear localization sequence and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Spinocerebellar ataxia-7 (one of a group of hereditary neurodegenrative diseases) is caused by an expanded CAG repeat in the gene encoding ataxin-7 (the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele). In cells where there is a mutation of the SCA7 gene, ataxin-7 accumulates in intranuclear inclusions and can result in cell death. Spinocerebellar ataxia (SCA) is one of a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. Frequently, atrophy of the cerebellum occurs.
Specificity
This antibody recognizes Ataxin-7 protein.
Immunogen
Epitope: Epitope mapped between aa 66 and aa 119.
Recombinant human Ataxin 7 as a fusion protein (aa 1 to aa 229).
Application
Anti-Ataxin-7 Antibody, clone 3SCA-1C1 is an antibody against Ataxin-7 for use in WB.
ELISA: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in ELISA, as reported by an outside laboratory. Immunocytochemistry: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in IC, as reported by an outside laboratory.
Research Category
Neuroscience
Neuroscience
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Neurodegenerative Diseases
Signaling Neuroscience
Neurodegenerative Diseases
Quality
Evaluated by Western Blotting of Rat brain lysate. Western Blotting: Representative lot data: A 1:1000 dilution of this antibody detected Ataxin-7 in 10ug of Rat brain tissue lysate.
Target description
96 kDa Calculated
Physical form
Unpurified
Unpurified mouse IgG1, k antibody in ascites fluid without preservatives.
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
Rat brain tissue lysate.
Rat brain tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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S Vijayalingam et al.
Journal of virology, 90(2), 1070-1079 (2015-11-13)
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