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890893P

Avanti

GL67

Avanti Research™ - A Croda Brand

Synonym(s):

N4-Cholesteryl-Spermine HCl salt

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About This Item

Empirical Formula (Hill Notation):
C38H70N4O2· 3HCl
CAS Number:
179075-30-0
Molecular Weight:
724.37
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (890893P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C

General description

N4-Cholesteryl-Spermine (GL67) comprises of the cationic lipid GL67 with spermine and cholesterol.

Application


  • GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.: This study explores the use of GL67 liposomes for delivering siRNA to human lung cancer cells, highlighting its potential for targeted cancer therapies (Jarallah et al., 2023).

  • Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.: The research focuses on the efficacy of GL67 liposomes in aerosol form for non-viral gene therapy in the lungs, demonstrating significant gene transfer efficiency (Le Gall et al., 2021).

  • Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.: The study investigates the enhancement of GL67-mediated gene transfer using low-frequency ultrasound, showing improved transfection in mouse lungs (Xenariou et al., 2010).

Biochem/physiol Actions

N4-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent.

Packaging

5 mL Amber Glass Screw Cap Vial (890893P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In vivo imaging of gene transfer to the respiratory tract
Griesenbach U, et al.
Biomaterials, 29(10), 1533-1540 (2008)

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