C0563
Cardiolipin sodium salt from bovine heart
≥97% (TLC), lyophilized powder
Synonym(s):
Diphosphatidylglycerol
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About This Item
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biological source
bovine heart
Quality Level
assay
≥97% (TLC)
form
lyophilized powder
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
General description
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.
Application
Cardiolipin sodium salt from bovine heart has been used:
- as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
- as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
- as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)
Biochem/physiol Actions
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.
Packaging
packaged under argon
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Lu Luo et al.
The Journal of biological chemistry, 289(46), 31708-31718 (2014-10-08)
Bax is a pro-apoptotic Bcl-2 family protein. The activated Bax translocates to mitochondria, where it forms pore and permeabilizes the mitochondrial outer membrane. This process requires the BH3-only activator protein (i.e. tBid) and can be inhibited by anti-apoptotic Bcl-2 family
Val A Fajardo et al.
Scientific reports, 7(1), 2060-2060 (2017-05-19)
Cardiolipin (CL) is a unique mitochondrial phospholipid that, in skeletal muscle, is enriched with linoleic acid (18:2n6). Together, CL content and CL 18:2n6 composition are critical determinants of mitochondrial function. Skeletal muscle is comprised of slow and fast fibers that
Effects of pure n-alkanes and crude oil on bacterial phospholipid classes and molecular species determined by electrospray ionization mass spectrometry
Mazzella N, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 40-53 (2005)
Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA
Fattal I, et al.
Immunology, 141(2), 276-285 (2014)
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to beta-barrel protein assembly and maintenance of mitochondrial morphology
Wideman JG, et al.
PLoS ONE, 8(8), e71837-e71837 (2013)
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