QBD10109

Acid-dPEG^®₅-NHS ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₁₈H₂₉NO₁₁
• Molecular Weight: 435.42
• MDL number: MFCD27952888
• UNSPSC Code: 12352106
• PubChem Substance ID: 329823879
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: cross-linking reagent; reactivity: amine reactive
• functional group: NHS ester; carboxylic acid
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O

Description

Features and Benefits

Acid-dPEG^®₅-NHS ester allows conjugation to two different moieties, each containing free amines. Because the single molecular weight dPEG^® spacers contain an N-hydroxysuccinimide ester only on one end of the spacer, greater control of the conjugation reaction can be maintained. The free acid end of the spacer can be left unreacted to modify the surface properties of the molecule to which it is conjugated, or the free acid end can be activated and conjugated to a different group at a later time. The dPEG^® spacers provide precise spacing/distance control, and the dPEG^® itself provides the well-known benefits of increased water solubility; decreased immunogenicity; protection from proteolysis; increased hydrodynamic volume; and increased serum half-life.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable