A88255

p-Anisidine

99%

• Synonym(s): 4-Aminoanisole, 4-Methoxyaniline
• Linear Formula: CH₃OC₆H₄NH₂
• CAS Number: 104-94-9
• Molecular Weight: 123.15
• Beilstein/REAXYS Number: 471556
• MDL number: MFCD00007864
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891372
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99%
• form: solid
• autoignition temp.: 959 °F
• bp: 240-243 °C (lit.)
• mp: 56-59 °C (lit.)
• SMILES string: COc1ccc(N)cc1
• InChI: 1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3
• InChI key: BHAAPTBBJKJZER-UHFFFAOYSA-N

Description

Application

p-Anisidine can undergo aerobic oxidation in the presence of gold catalysts to form aromatic azo compounds.
p-Anisidine can be used:

• In the diastereoselective and enantioselective synthesis of CF₃-substituted azoridines catalyzed by a chiral Bronsted acid.
• To prepare 4-organoselenium-quinolines through multi-component Povarov reaction with ethyl glyoxylate and ethynyl(phenyl)selane, catalyzed by Yb(OTf)₃.
• As a starting material to synthesize 3-fluoro-6-methoxyquinoline in two steps.,
• To prepare N-PMP protected α-aminopropargylphosphonates by reacting with terminal alkynes and diethyl formylphosphonate hydrate using silver(I) triflate as a catalyst.

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H350,H373,H400
• pcodes: P202 - P260 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Carc. 1B - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 251.6 °F - closed cup
• flash_point_c: 122 °C - closed cup