914487
2-(Diphenylphosphanyl)benzamide
≥95%
Synonym(s):
2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
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About This Item
Empirical Formula (Hill Notation):
C19H16NOP
CAS Number:
Molecular Weight:
305.31
UNSPSC Code:
12352200
NACRES:
NA.22
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General description
It is recommended to make fresh stock stolutions prior to each use.
Application
2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).
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Description
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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Ji Luo et al.
Nature chemistry, 8(11), 1027-1034 (2016-10-22)
Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small-molecule switch that can be used to control protein activity. The approach uses a phosphine-mediated Staudinger
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