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667544

Sigma-Aldrich

Lithium chloride solution

0.5 M in anhydrous tetrahydrofuran

Synonym(s):

Lithium chloride, Lithium monochloride

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About This Item

Linear Formula:
LiCl
CAS Number:
7447-41-8
Molecular Weight:
42.39
MDL number:
MFCD00011078
UNSPSC Code:
12352302
PubChem Substance ID:
24884921
NACRES:
NA.22

concentration

0.5 M in anhydrous tetrahydrofuran

impurities

≤50 ppm water

density

0.913 g/mL at 25 °C

SMILES string

[Li+].[Cl-]

InChI

1S/ClH.Li/h1H;/q;+1/p-1

InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

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Application

Lithium chloride (LiCl) is a source of nucleophilic chloride anion and it can convert alcohols to alkyl chlorides. It catalyzes the ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA). LiCl solution is also used in the preparation of organozinc halides.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN3796
SHBL7230
SHBK0127
SHBJ9471
SHBJ3648

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On-demand synthesis of organozinc halides under continuous flow conditions.
Berton, Mateo et al.
Nature Protocols, 13(1), 324-324 (2018)
Lithium Chloride.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Lekha Gupta et al.
The Journal of organic chemistry, 74(5), 2231-2233 (2009-02-05)
Ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA) in THF at -78 degrees C reveal substantial accelerations by as little as 0.5 mol % of LiCl (relative to LDA). Substrate dependencies suggest a specific range of reactivity
Sima Rahman et al.
PloS one, 7(12), e51746-e51746 (2012-12-29)
Lineage allocation of the marrow mesenchymal stem cells (MSCs) to osteoblasts and adipocytes is dependent on both Wnt signaling and PPARγ2 activity. Activation of PPARγ2, an essential regulator of energy metabolism and insulin sensitivity, stimulates adipocyte and suppresses osteoblast differentiation
Qi Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14765-14770 (2013-08-22)
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved
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