653233

2,4-Dichloro-5-fluoropyrimidine

97%

• Empirical Formula (Hill Notation): C₄HCl₂FN₂
• CAS Number: 2927-71-1
• Molecular Weight: 166.97
• MDL number: MFCD00233551
• UNSPSC Code: 12352100
• PubChem Substance ID: 24883938
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• form: solid
• mp: 37-41 °C (lit.)
• functional group: chloro; fluoro
• SMILES string: Fc1cnc(Cl)nc1Cl
• InChI: 1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
• InChI key: WHPFEQUEHBULBW-UHFFFAOYSA-N

Description

Application

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314,H317
• pcodes: P260 - P272 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 222.8 °F - closed cup
• flash_point_c: 106 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges