Skip to Content
MilliporeSigma
All Photos(5)

Key Documents

View All Documentation

440744

Sigma-Aldrich

Polycaprolactone

average Mn 80,000

Synonym(s):

2-Oxepanone homopolymer, 6-Caprolactone polymer

Sign Into View Organizational & Contract Pricing
All Photos(5)

About This Item

Linear Formula:
(C6H10O2)n
UNSPSC Code:
12162002
NACRES:
NA.23

form

pellets (~3 mm)

Quality Level

200

mol wt

average Mn 80,000

impurities

<0.5% water

mp

60 °C (lit.)

density

1.145 g/mL at 25 °C

Mw/Mn

<2

application(s)

3D bioprinting
advanced drug delivery

SMILES string

C1CCC(=O)OCC1 (Canonical-SMILES)

InChI

1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2

InChI key

PAPBSGBWRJIAAV-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
  • It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
  • Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.

Application

  • PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
  • Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
  • PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
  • Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
  • Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

Features and Benefits

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

Related product

Product No.
Description
Pricing

911593

NanoFabTx™ microfluidic - nano, device kit for synthesis of 100-200 nm nanoparticles and liposomes

911860

NanoFabTx™ microfluidic - micro, device kit for synthesis of 1-5 μm particles

911879

NanoFabTx™ microfluidic - micro, device kit for synthesis of 10-30 μm particles

909637

NanoFabTx™ PLGA-nano, for synthesis of 100 and 200 nm particles

912212

NanoFabTx™ PLGA-micro, for synthesis of 10-30 um particles

912220

NanoFabTx™ PLGA-micro, for synthesis of 1-5 μm particles

920436

NanoFabTx™ PEG-PLA drug formulation screening kit, for synthesis of PEGylated nanoparticles

915408

NanoFabTx™ PEGylated nanoparticle formulation screening kit

917796

NanoFabTx™ PEG-PLGA drug formulation screening kit, for synthesis of PEGylated nanoparticles

918881

NanoFabTx™ PEG-PCL drug formulation screening kit, for synthesis of PEGylated nanoparticles

918075

NanoFabTx™ PLA-nano, for synthesis of 100 and 200 nm particles

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCR0871
MKCP4069
MKCN0487
MKCL0177
MKCK0262

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Resomer&#174; C 209, Poly(caprolactone) ester terminated

Sigma-Aldrich

769762

Resomer® C 209, Poly(caprolactone)

Hung-Jen Shao et al.
Journal of biomedical materials research. Part A, 100(12), 3344-3352 (2012-06-27)
The phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) on different ratio of chitosan/polycaprolactone (PCL) blends were investigated in this study. The results showed that hBMSCs existed different morphology on chitosan/PCL blends due to the different adhesion characteristic of
Cevat Erisken et al.
Tissue engineering. Part A, 17(9-10), 1239-1252 (2010-12-30)
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly
T Limongi et al.
Molecular neurobiology, 55(12), 8788-8798 (2018-03-31)
Biopolymers are increasingly employed for neuroscience applications as scaffolds to drive and promote neural regrowth, thanks to their ability to mediate the upload and subsequent release of active molecules and drugs. Synthetic degradable polymers are characterized by different responses ranging
Wendi Zhang et al.
Biomaterials, 34(27), 6495-6503 (2013-06-04)
Coating the polycation/DNA binary complexes with PEGylated polyanions can improve long-circulation and biocompatibility in vivo. However, it has been certificated PEG dilemma can reduces gene transfection efficiency because of inhibition in cellular uptake and endosomal escape. Herein, two PEGylated anionic
Wei Ching Low et al.
Biomaterials, 34(14), 3581-3590 (2013-02-19)
At present, the recovery prospect for patients with chronic neurodegenerative diseases or acute trauma in the central nervous system is sub-optimal. The controlled differentiation of neural stem/progenitor cells (NPCs) to functional neurons is a possible treatment strategy. In contrast to
View All Related Papers

Articles

Three-Dimensional Printing of Tissue Engineering Scaffolds

We will explore the technological advances that have contributed toward the progress of 3DP of tissue engineering scaffolds, current materials used to create 3DP scaffolds, and the challenges that remain.

Bioprinting for Tissue Engineering and Regenerative Medicine

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

Biodegradable Aliphatic Polyesters for Drug Delivery

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service