MilliporeSigma
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440744

Sigma-Aldrich

Polycaprolactone

average Mn 80,000

Synonym(s):
2-Oxepanone homopolymer, 6-Caprolactone polymer
Linear Formula:
(C6H10O2)n
NACRES:
NA.23

form

pellets (~3 mm)

Quality Level

mol wt

average Mn 80,000

impurities

<0.5% water

mp

60 °C (lit.)

density

1.145 g/mL at 25 °C

Mw/Mn

<2

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General description

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
  • It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
  • Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.

Application

  • PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
  • Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
  • PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
  • Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
  • Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

Packaging

5, 250, 500 g in poly bottle

Features and Benefits

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

230.0 °F

Flash Point(C)

> 110 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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