Skip to Content
MilliporeSigma
All Photos(4)

Key Documents

View All Documentation

408727

Sigma-Aldrich

Polyethylenimine, branched

average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched

Synonym(s):

aziridine, homopolymer, PEI

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Linear Formula:
H(NHCH2CH2)nNH2
CAS Number:
9002-98-6
MDL number:
MFCD00084427
UNSPSC Code:
12162002
PubChem Substance ID:
24865591
NACRES:
NA.23

form

viscous liquid

mol wt

average Mn ~10,000 by GPC
average Mw ~25,000 by LS

impurities

≤1% water

refractive index

n20/D 1.5290

viscosity

13,000-18,000(50 °C)

bp

250 °C (lit.)

density

1.030 g/mL at 25 °C

SMILES string

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.

Application

Polyethyleneimine can be used as a non-viral synthetic polymer vector for in vivo delivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.

PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2 absorption and gene delivery.

Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.

Features and Benefits

Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties.

Branched PEI has better complexation andbuffering capacity.

Physical form

Branched polymer

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCG2017
BCCF5869
BCCD7752
BCCD5068
BCCD1909

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hsuan-Wen Chiu et al.
Oncotarget, 8(55), 94129-94141 (2017-12-08)
The betanodavirus B2 protein targets the mitochondria and acts as a "death factor", but its effect on lung cancer cells is unknown. We examined the effect of the B2 protein on triggering apoptosis or necroptosis
Q Tu et al.
Oncogene, 37(1), 128-138 (2017-09-12)
Pancreatic cancer is among the deadliest malignancies; however, the genetic events that lead to pancreatic carcinogenesis in adults remain unclear. In vivo models in which these genetic alterations occur in adult animals may more accurately reflect the features of human
Baoshun Lin et al.
Medicine, 94(31), e1301-e1301 (2015-08-08)
As an immunotoxin, diphtheria toxin has been widely used in gene therapy and gene function assays for its roles in protein synthesis inhibition, and the aim of our study is to set up a nonintegrating lentiviral system for specific expression
Wei Dong et al.
Frontiers in immunology, 9, 2312-2312 (2018-10-26)
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune responses against heterologous virus strains in animal models. Here we investigated whether sequential immunization with antigenically distinct influenza vaccines can also provide cross-protection. To this end, we compared immune responses
Gavin Ka Yu Siu et al.
Scientific reports, 6, 23464-23464 (2016-03-25)
Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the
View All Related Papers

Articles

Novel Inks for Direct-Write Assembly of 3-D Periodic Structures

New methods for materials fabrication at the micro- and nanoscale will drive scientific and technological advances in areas of materials science, chemistry, physics, and biology. The broad diversity of potentially relevant materials, length scales, and architectures underscores the need for flexible patterning approaches. One important example is the fabrication of 3D periodic structures composed of colloidal, polymeric, or semiconductor5 materials.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems

The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service