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361798

Sigma-Aldrich

Lithium diisopropylamide solution

2.0 M in THF/heptane/ethylbenzene

Synonym(s):
LDA
Linear Formula:
[(CH3)2CH]2NLi
CAS Number:
Molecular Weight:
107.12
Beilstein:
3655042
MDL number:
PubChem Substance ID:
NACRES:
NA.22

form

liquid

Quality Level

concentration

2.0 M in THF/heptane/ethylbenzene

impurities

3 wt. % diisopropylamine

density

0.812 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

[Li]N(C(C)C)C(C)C

InChI

1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1

InChI key

ZCSHNCUQKCANBX-UHFFFAOYSA-N

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General description

Lithium diisopropylamide solution (LDA) is a sterically hindered non-nucleophilic strong base widely used in organic synthesis.

Application

Lithium diisopropylamide solution (LDA) can be used:
  • As an initiator in the anionic polymerization of D,L-lactide and methyl methacrylate.
  • To facilitate ester enolization.
  • To convert carboxylic acids to enediolate intermediates for preparing trifluoromethyl ketones.
  • In ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.
  • To catalyze ortholithiation and Fries rearrangement of aryl carbamates.
  • As a promoter in the isomerization of allylic ethers to (Z)-propenyl ethers.

Packaging

4×25, 100, 4×100, 800 mL in Sure/Seal™
The 25 mL Sure/Seal bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Signal Word

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT RE 2

Target Organs

hearing organs

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup

Certificate of Analysis

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Certificate of Origin

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