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Sigma-Aldrich

2-Bromo-5-(trifluoromethyl)aniline

97%

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About This Item

Linear Formula:
BrC6H3(CF3)NH2
CAS Number:
454-79-5
Molecular Weight:
240.02
EC Number:
207-227-6
MDL number:
MFCD00007637
UNSPSC Code:
12352100
PubChem Substance ID:
24853035
NACRES:
NA.22

assay

97%

form

liquid

refractive index

n20/D 1.522 (lit.)

density

1.675 g/mL at 25 °C (lit.)

SMILES string

Nc1cc(ccc1Br)C(F)(F)F

InChI

1S/C7H5BrF3N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2

InChI key

PZDVFXUBTKPFSG-UHFFFAOYSA-N

Application

2-Bromo-5-(trifluoromethyl)aniline was used in the synthesis and biochemical evaluation of series of inhibitors of hepatitis C virus (HCV) NS3 protease.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Robert Rönn et al.
Bioorganic & medicinal chemistry, 16(6), 2955-2967 (2008-01-16)
Inhibition of the hepatitis C virus (HCV) NS3 protease has emerged as an attractive approach to defeat the global hepatitis C epidemic. In this work, we present the synthesis and biochemical evaluation of HCV NS3 protease inhibitors comprising a non-natural

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