109274

2-Chloropropionic acid

92%

• Synonym(s): (±)-2-Chloropropionic acid
• Linear Formula: CH₃CHClCOOH
• CAS Number: 598-78-7
• Molecular Weight: 108.52
• Beilstein/REAXYS Number: 1720259
• EC Number: 209-952-3
• MDL number: MFCD00004224
• UNSPSC Code: 12352100
• eCl@ss: 39050312
• PubChem Substance ID: 24846904
• NACRES: NA.22

Properties

• vapor pressure: 4 mmHg ( 20 °C)
• Quality Level: 100
• assay: 92%
• refractive index: n20/D 1.4345 (lit.)
• bp: 170-190 °C (lit.)
• solubility: H₂O: soluble
• density: 1.182 g/mL at 25 °C (lit.)
• functional group: carboxylic acid; chloro
• SMILES string: CC(Cl)C(O)=O
• InChI: 1S/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)
• InChI key: GAWAYYRQGQZKCR-UHFFFAOYSA-N

Description

General description

(S)-2-Chloropropionic acid is the building block for the synthesis of aryloxyphenoxypropionic acid herbicides. 2-Chloropropionic acid is the raw material for production of pesticides, dyestuffs and agro- and forest chemicals.

Application

• 2-Chloropropionic acid is used in the preparation of propargyl 2-chloropropionate (PCP), an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.
• It can be employed in the synthesis of a biologically active chitin derivative, (1-carboxyethyl) chitosan.
• It can be treated with o-phenylenediamine phosphate to synthesize benzimidazole derivatives.

Biochem/physiol Actions

2-Chloropropionic acid on oral administration induces necrosis of granule cell layer of rat cerebellum.

Other Notes

Contains 2,2-dichloropropionic acid

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314
• pcodes: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 4 Oral - Skin Corr. 1A
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: 215.6 °F - closed cup
• flash_point_c: 102 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter